Patients took either low or high doses of lisinopril for up to 5 years.
The study used low lisinopril doses of 2.5 to 5mg per day and high lisinopril doses of 32.5 to 35mg per day during the trial.
These findings contradict a theory that aspirin might reduce ACE inhibitor benefit in heart failure patients.
Researchers studied mortality data on 11,575 CAD patients who were screened for a heart attack prevention trial.
Eighty-one percent of these patients filled an ACE inhibitor prescription within 30 days.
After a year, only 66% of these patients were still filling their prescriptions.
Source: June 2, 2004, Volume 43, Issue 11 Pages 2036-2043. James Mason collected data on 7,487 patients taking enalapril (Vasotec) at the start of a medical trial. Researchers studied how many patients stopped treatment (seeing if they tolerated the drug) within a year of starting it for the first time. During the test dose part of the trial, only 8% of patients reported side effects; 2% of those patients stopped taking the drug because of their side effects.They compared 579 patients taking ACE inhibitors only (the control group) to 618 patients taking both ACE inhibitors and aspirin.After a 5 year follow-up, the authors found that mortality was higher in patients taking only ACE inhibitors (27%) than in patients taking both ACE inhibitors and aspirin (19%).1999;20-1925 May, 1995 - The SOLVD trial showed that enalapril (Vasotec) greatly improves quality of life for patients with left ventricular dysfunction.In this sub-study we examined changes in heart structure and heart function in SOLVD patients to see if enalapril slowed remodeling.